Vascular disorders: flow, pressure, and vessel integrity.
Welcome back! In Part 1, you mastered the heart's structure and electrical system. In Part 2, you learned what happens when the heart factory fails — CAD, MI, heart failure, and hypertension.
Now in Part 3, we leave the heart factory and travel the Vascular Highway System — the massive network of arteries and veins that carry blood to every cell factory in your body. You will learn what happens when highways get blocked (PAD), when traffic clots (DVT), when a clot travels to the lungs (PE), and when highway walls balloon out (aneurysms).
🎯 What You Will Master:
💜 LPN Scope Reminder: LPNs COLLECT DATA and REPORT! RNs ASSESS and DIAGNOSE!
Enter your name to begin:
Understanding arteries, veins, and capillaries as the body's transportation network
Imagine your body as a massive industrial complex with millions of cell factories. Every factory needs supply trucks delivering oxygen and nutrients, and waste removal trucks hauling away carbon dioxide and metabolic waste.
The vascular system is this transportation network! It has three types of "roads":
Job: The "Traffic Controller" — constricts and dilates blood vessels to control blood flow and pressure.
Where: Tunica media layer of arteries and veins.
Key Receptors: Alpha-1 (constrict), Beta-2 (dilate), calcium channels (contract when Ca²⁺ enters).
When damaged: Atherosclerosis, PAD, aneurysm formation.
Job: The "Highway Maintenance Crew" — lines all blood vessels, keeps blood flowing smoothly.
Where: Inner lining (tunica intima) of ALL blood vessels.
Special Powers: Releases nitric oxide to dilate vessels. Prevents clots by being smooth.
When damaged: Clots form! Atherosclerosis begins. DVT can develop.
Job: The "Emergency Road Repair Crew" — rushes to damaged vessel walls and forms a plug to stop bleeding.
Where: Floating in the blood, always patrolling.
Key Receptor: ADP receptor (clopidogrel blocks this!), COX enzyme (aspirin blocks this!).
When overactive: Unwanted clots = DVT, PE, stroke, MI.
Job: The "Clotting Factor Factory" — manufactures clotting factors II, VII, IX, and X using Vitamin K.
Where: Liver.
Drug Target: Warfarin blocks Vitamin K HERE, reducing clotting factor production.
Key Lab: PT/INR measures how well warfarin is working at this factory.
This is one of the MOST TESTED concepts on NCLEX! You MUST be able to distinguish arterial problems from venous problems. The signs are OPPOSITE!
| Feature | 🔴 ARTERIAL Disease | 🔵 VENOUS Disease |
|---|---|---|
| Pain | Intermittent claudication (pain with walking, relieved by rest). Rest pain at night — wakes client up! | Dull aching after standing. Feeling of fullness. Relieved by ELEVATION. |
| Skin Color | Pale, gray-blue, cool. Elevational pallor. Dependent rubor (red when hanging down). | Brown discoloration (stasis dermatitis). Warm skin. Cyanotic when dependent. |
| Pulses | Decreased or ABSENT! | Present (normal) |
| Edema | Minimal or absent | SIGNIFICANT edema! Ankle swelling is prominent. |
| Skin/Hair | Shiny, dry, scaly. Hair loss. Thickened toenails. | Stasis dermatitis. Brown pigmentation. |
| Ulcers | Between/on toes or top of foot. PAINFUL! Deep, pale base. | Around ankles (medial malleolus). Uneven edges. Pink bed with granulation. |
| Leg Position | Keep legs LEVEL or slightly DEPENDENT. Do NOT elevate above heart! | ELEVATE legs! Helps blood return to heart. |
| Temperature | COOL or COLD | WARM |
ARTERIAL = "A" for ABSENT pulses, ACHING with activity, pale And cold
VENOUS = "V" for VISIBLE edema, VARICOSE veins, and ELEVATE to help!
Leg Position Rule: "Arteries go DOWN (or level), Veins go UP!" — Arterial disease = keep dependent to let gravity help blood flow down. Venous disease = elevate to help blood return against gravity.
LPNs COLLECT DATA and REPORT! RNs ASSESS and DIAGNOSE!
When the NCLEX asks you to "recognize cues" for vascular problems, look for these patterns:
Score 80% to unlock Peripheral Arterial Disease!
The LPN is collecting data on a client with peripheral vascular disease. Which finding is MOST characteristic of ARTERIAL disease?
A client with vascular disease has pain that occurs when walking and is relieved by rest. The LPN recognizes this as:
Which leg positioning instruction is correct for a client with peripheral ARTERIAL disease?
The LPN is monitoring a client with deep vein thrombophlebitis. Which finding requires IMMEDIATE notification of the RN?
Which layer of the arterial wall contains smooth muscle cells that control constriction and dilation?
The LPN is reinforcing teaching to a client about preventing deep vein thrombosis after hip surgery. Which instruction is MOST important?
A client with venous insufficiency has brown discoloration along the ankles. The LPN understands this is caused by:
The LPN collects data on a client and notes the following: cold, pale right foot; absent right dorsalis pedis pulse; pain with ambulation; shiny, hairless skin on the right leg. These findings are MOST consistent with:
Veins differ from arteries in that veins have:
Which of the following are components of Virchow's Triad for clot formation? Select ALL that apply.
The client with a DVT has a prescription for bed rest with the affected leg elevated. The LPN knows that the MOST important reason for elevation is to:
The LPN is caring for a client with suspected DVT. Which action should the LPN AVOID?
The endothelial cells that line blood vessels are important because they:
A client with PAD asks why they should avoid applying a heating pad directly to their legs. The BEST response by the LPN is:
The LPN understands that Virchow's Triad explains the risk factors for developing:
When the supply highways get blocked — PAD, Raynaud's, and Buerger's Disease
Peripheral Arterial Disease (PAD) is a chronic disorder where partial or total arterial occlusion deprives the lower extremities of oxygen and nutrients. Tissue damage occurs BELOW the level of the blockage.
The #1 cause of PAD is atherosclerosis — the same plaque buildup you learned about in Part 2, but now it is happening in the leg arteries instead of the coronary arteries!
Think of the leg arteries as supply highways to millions of muscle and skin cell factories in your legs and feet. When atherosclerotic plaque builds up and narrows these highways, the delivery trucks (red blood cells carrying oxygen) cannot get through. The cell factories downstream starve for oxygen, causing pain, tissue damage, and eventually gangrene if untreated.
Critical threshold: When an artery is narrowed by 50% in the left main or 75% in any major branch, the blockage is considered significant.
DO NOT:
Raynaud's disease is a vasospasm of the arterioles and arteries of the upper and lower extremities. The vasospasm causes constriction of the cutaneous vessels.
Triggers: Exposure to COLD or STRESS — these cause the smooth muscle cells in the arterial walls to go into spasm!
Primarily affects: Fingers, toes, ears, and cheeks.
1. WHITE (Blanching)
Vasospasm cuts off blood flow. Fingers turn WHITE and NUMB.
2. BLUE (Cyanosis)
Tissue becomes oxygen-deprived. Turns BLUE with tingling.
3. RED (Reperfusion)
Vasospasm releases. Blood rushes back. REDDENED and SWOLLEN.
Buerger's disease is an occlusive disease of the median and small arteries AND veins. The distal upper and lower limbs are affected most commonly.
KEY FACT FOR NCLEX: Buerger's disease is found primarily in YOUNG MEN who SMOKE. The cause is unknown but has an autoimmune component. Smoking cessation is the #1 treatment!
Interventions: Same as Raynaud's disease plus SMOKING CESSATION is the most critical intervention!
When the NCLEX gives you a scenario, look for these KEY CUES:
When PAD progresses to gangrene or uncontrolled infection, amputation may be necessary. Complications include hemorrhage, infection, phantom limb pain, neuroma, and flexion contractures.
"First 24: FOOT UP, not the STUMP!" — Elevate the foot of the BED (not the stump itself on pillows) to reduce edema.
"After 24: Go PRONE!" — Prone position stretches hip flexors and prevents contractures.
"Never pillow the stump!" — Placing the residual limb on a pillow causes hip flexion contracture that makes prosthesis fitting impossible!
Score 80% to unlock Venous Disorders!
A client with PAD reports pain in the calf muscles when walking that is relieved by rest. The LPN documents this as:
The LPN is reinforcing teaching to a client with PAD. Which statement by the client indicates a NEED for further teaching?
A 24-year-old male presents with claudication in the arch of the foot and superficial thrombophlebitis. The LPN should check the client's history for:
A client with Raynaud's disease asks what can be done to manage the condition. The LPN's BEST response is:
The classic color change pattern in Raynaud's disease during an attack is:
Following a below-knee amputation, the LPN understands that the client should be positioned PRONE to:
The LPN caring for a client 12 hours after above-knee amputation should AVOID which action?
A client with PAD is instructed about exercise. The LPN reinforces which instruction?
The LPN is collecting data on a client after femoral-popliteal bypass surgery. Which finding should be reported IMMEDIATELY?
The most common cause of peripheral arterial disease is:
An arterial ulcer is MOST likely found:
The LPN notes that a client with PAD has BP readings at the ankle that are LOWER than the brachial pressure. This finding:
The client asks about phantom limb pain after amputation. The LPN's BEST response is:
A client with PAD has been prescribed cilostazol. The LPN understands this medication works by:
Collateral circulation refers to:
When return traffic clots, valves fail, and blood pools in the legs
Deep Vein Thrombophlebitis (DVT) is the formation of a blood clot in a deep vein, most commonly in the legs. It is MORE SERIOUS than superficial thrombophlebitis because of the risk for PULMONARY EMBOLISM!
When blood flow slows down in the veins (stasis), the blood becomes like traffic stopped on a highway. Platelets start sticking together. Fibrin weaves around them like a net. A CLOT forms, blocking the vein and causing swelling behind it. The REAL DANGER? If the clot breaks free, it travels through the venous system → right side of the heart → LUNGS = Pulmonary Embolism!
1. STASIS (slow blood flow) +
2. ENDOTHELIAL INJURY (vessel wall damage) +
3. HYPERCOAGULABILITY (blood that clots too easily) =
⚠ CLOT FORMATION (THROMBOSIS)!
Varicose veins are dilated, tortuous veins that result from incompetent valves in the veins. The vein walls weaken, dilate, and the one-way valves become unable to prevent backflow.
Place client supine with legs elevated. When client sits up, if varicosities are present, veins fill from the PROXIMAL end. (Normally, veins fill from the DISTAL end.)
Venous insufficiency results from prolonged venous hypertension which stretches the veins and damages the valves. This causes edema, venous stasis ulcers, swelling, and cellulitis.
Score 80% to unlock Pulmonary Embolism!
Which action is CONTRAINDICATED when caring for a client with DVT?
The LPN is monitoring a client receiving heparin for DVT. Which lab value is used to monitor heparin effectiveness?
The antidote for heparin overdose is:
A venous stasis ulcer is MOST commonly located:
Antiembolism stockings for venous insufficiency should be applied:
The LPN understands that DVT is more dangerous than superficial thrombophlebitis because of the risk for:
Which is a risk factor for DVT development? Select ALL that apply.
The Trendelenburg test is used to evaluate:
The LPN is administering subcutaneous heparin. Which technique is CORRECT?
A client on warfarin has an INR of 4.5. The LPN should:
The LPN monitors a client on heparin for signs of bleeding. Which finding should be reported?
A client on warfarin asks about diet. The LPN reinforces which instruction?
The D-dimer blood test is used to help diagnose:
The therapeutic aPTT range for a client receiving continuous IV heparin is:
A client with DVT asks why they cannot get out of bed. The LPN's BEST response is:
When a clot travels to the lungs — Recognize it. Report it. SAVE A LIFE.
A pulmonary embolism (PE) occurs when a thrombus (most commonly from a deep vein in the leg) detaches, travels to the RIGHT side of the heart, and lodges in a branch of the pulmonary artery, blocking blood flow to the lungs.
THIS IS A MEDICAL EMERGENCY! IT CAN BE FATAL!
Diagnostic Tests:
"CHEST PAIN + CAN'T BREATHE + FAST HEART + SCARED = THINK PE!"
NCLEX Strategy: When a question describes a post-surgical or immobilized client who suddenly develops chest pain and shortness of breath, the answer is almost always PULMONARY EMBOLISM. Do not confuse with MI (which has different risk factors and presentation).
Score 80% to unlock Aortic Aneurysms!
A client 1 day post hip surgery suddenly develops chest pain, dyspnea, and tachycardia. The LPN suspects:
The FIRST action by the LPN when PE is suspected is:
A normal D-dimer level is:
The PREFERRED diagnostic test for confirming pulmonary embolism is:
Which client is at HIGHEST risk for developing a pulmonary embolism?
The client with suspected PE should be positioned:
Blood-tinged sputum in a client with suspected PE is caused by:
Fat embolism is a potential complication of:
The LPN is caring for a client with DVT who suddenly complains of chest pain and anxiety. Which finding BEST confirms the LPN's suspicion of PE?
The MOST important preventive measure for PE is:
A client diagnosed with DVT 1 day ago suddenly has chest pain and shortness of breath. The LIFE-THREATENING complication the LPN should suspect is:
Which breath sounds would the LPN expect to hear in a client with PE?
Fill in the blank: Pulmonary embolism occurs when a thrombus from a deep vein detaches and travels to the ______________ side of the heart, then lodges in the ______________ artery.
The medication initially prescribed for PE treatment is typically:
Petechiae over the chest and axilla in a client with a recent long bone fracture suggests:
Understanding types, recognition, and emergency management
An aortic aneurysm is an abnormal dilation of the arterial wall caused by localized weakness and stretching in the medial layer (tunica media) of the aorta.
Cell Factory Explanation: The smooth muscle cells and elastic fibers in the tunica media are the wall's "structural support beams." When these get damaged by atherosclerosis, hypertension, or connective tissue disorders, the wall weakens. Blood pressure pushes against the weak spot, causing it to balloon outward — like a weak spot on a tire!
Goal of treatment: Limit progression, control BP, recognize symptoms early, and PREVENT RUPTURE!
Diffuse dilation involving the ENTIRE circumference of the arterial segment. Like a sausage-shaped bulge.
Distinct localized outpouching of the artery wall. Like a balloon poking out from one side.
Blood separates the layers of the artery wall, forming a cavity between them. EXTREMELY dangerous!
Clot and connective tissue OUTSIDE the arterial wall. Occurs from vessel injury or trauma to all three layers.
⚠ RUPTURE = SURGICAL EMERGENCY! NOTIFY IMMEDIATELY!
❌ AVOID PALPATING the abdomen if an abdominal aneurysm is suspected!
Score 80% to unlock Medications!
A client with an abdominal aortic aneurysm suddenly complains of severe back pain. The LPN should FIRST:
The LPN should AVOID which action when caring for a client with a suspected abdominal aortic aneurysm?
After abdominal aortic aneurysm repair, the LPN monitors urine output. Which finding requires immediate notification?
An aortic aneurysm is caused by weakness in which layer of the arterial wall?
A pulsating abdominal mass with a systolic bruit is a characteristic finding of:
After aortic aneurysm repair, the head of the bed should be limited to:
Hoarseness and difficulty swallowing in a client suggests a possible:
The type of aneurysm where blood separates the layers of the artery wall is called:
Post-operative teaching after abdominal aortic aneurysm repair includes avoiding lifting objects heavier than:
Signs of graft occlusion after vascular surgery include all EXCEPT:
Pharmacological management of an aortic aneurysm primarily focuses on:
The LPN instructs a client with an aortic aneurysm to report which symptom IMMEDIATELY?
An embolectomy is a procedure to:
After an embolectomy, the LPN should monitor the affected extremity for which complication related to reperfusion?
Diagnostic tests used to confirm an aortic aneurysm include all of the following EXCEPT:
Anticoagulants, thrombolytics, antiplatelets, and vasodilators
Understanding WHERE drugs work on the clotting cascade is KEY for NCLEX! Think of clotting as an assembly line in a factory. Different drugs shut down different parts of the assembly line.
Cell Factory: Platelets are the "first responders" that form a plug. Clotting factors (made by liver hepatocyte factories) weave fibrin to make the plug permanent. Each drug class targets a different part of this factory assembly line!
| Drug Class | Examples | Target/Action | Lab Monitor | Antidote |
|---|---|---|---|---|
| Heparin (UFH) | Heparin sodium | Enhances antithrombin III; blocks intrinsic pathway. IMMEDIATE effect! | aPTT (1.5-2.5x normal) | PROTAMINE SULFATE |
| LMWH | Enoxaparin (Lovenox), Dalteparin | Same as heparin but longer half-life. SubQ abdomen only! | aPTT, platelets | Protamine sulfate |
| Warfarin | Coumadin | Blocks Vitamin K → decreases clotting factors II, VII, IX, X. Takes 3-5 DAYS! | PT/INR (INR 2-3) | VITAMIN K (phytonadione) |
| DOACs | Rivaroxaban (Xarelto), Apixaban (Eliquis), Dabigatran (Pradaxa) | Direct thrombin inhibitors; block thrombin directly | NONE routine! | Idarucizumab (dabigatran only) |
| Antiplatelets | Aspirin, Clopidogrel (Plavix) | Block platelet aggregation. ASA blocks COX; Plavix blocks ADP receptor | Bleeding time | None specific. Platelet transfusion. |
| Thrombolytics | Alteplase (tPA), Tenecteplase | DISSOLVE existing clots! Activate plasminogen. Used for acute MI, stroke, massive PE | Fibrinogen, aPTT | Aminocaproic acid |
| Peripheral Vasodilators | Prazosin, Pentoxifylline | Decrease peripheral resistance; increase blood flow to extremities. Best for Raynaud's | BP, heart rate | N/A |
"Pro-H" = PROtamine sulfate for Heparin
"K for Coumadin" = Vitamin K for warfarin (Coumadin)
"H = aPTT, W = INR" = Heparin monitored by aPTT; Warfarin monitored by INR
Drug Suffixes: -parin = heparin type | -xaban = DOAC | -pidogrel = antiplatelet
Score 80% to unlock the Final Exam!
The antidote for warfarin overdose is:
A client on heparin has an aPTT of 120 seconds (normal: 30-40). The LPN should:
Which lab test monitors warfarin effectiveness?
Clopidogrel (Plavix) works by:
Thrombolytic drugs (like alteplase/tPA) are used to:
A major advantage of DOACs over warfarin is:
Peripheral vasodilators are MOST effective for which condition?
HIT (Heparin-Induced Thrombocytopenia) is indicated by:
Warfarin takes how long to reach therapeutic effect?
The LPN notes hematuria in a client on anticoagulation. The PRIORITY action is:
Aspirin works as an antiplatelet by blocking:
When drawing blood for aPTT on a client with continuous IV heparin, blood should be drawn:
Side effects of peripheral vasodilators include:
Bridge therapy refers to:
A client on warfarin asks about taking ibuprofen. The LPN's BEST response is:
Covers ALL sections! Score 80% to earn your CV3 Vascular Disorders Certificate!
A post-surgical client on bed rest suddenly develops dyspnea, chest pain, and tachycardia. The LPN's PRIORITY action is:
Cold, pale legs with absent pulses and pain during walking indicate:
Protamine sulfate is the antidote for:
The LPN should AVOID palpating the abdomen of a client with a suspected:
A client with DVT should have the affected leg positioned:
The classic triad of signs for Raynaud's disease is:
For the first 24 hours after a below-knee amputation, the stump should be:
The therapeutic INR range for standard warfarin therapy is:
Intermittent claudication is BEST described as:
Virchow's Triad includes all EXCEPT:
Fill in the blank: Arterial disease causes legs that are _______ and _______, while venous disease causes legs that are _______ and _______.
The most reliable diagnostic sign of DVT is:
A client with PAD should be instructed to:
Buerger's disease (thromboangiitis obliterans) is MOST commonly seen in:
Brown discoloration along the ankles extending up the calf is characteristic of:
Petechiae over the chest and axilla in a client with a recent femur fracture suggests:
The 6 P's of neurovascular compromise include all EXCEPT:
A client taking warfarin asks about eating salads. The BEST instruction is:
After aortic aneurysm graft repair, cold/pale extremities distal to the graft with absent pulses indicate:
Antiembolism stockings should be applied:
A client with suspected PE should be positioned with:
The LPN is caring for a client receiving alteplase (tPA) for massive PE. Which action is MOST important?
A dissecting aortic aneurysm is dangerous because:
The LPN reinforces teaching for a client going home on warfarin. Which statement by the client shows CORRECT understanding?
The LPN collects data on a client with unilateral leg swelling, warmth, and tenderness. A positive D-dimer of 500 ng/mL is obtained. The LPN suspects:
This certifies that
has successfully completed
CV Part 3: Vascular Disorders
PAD • DVT • PE • Aneurysms • Anticoagulation
with 115+ NCLEX-PN Practice Questions
Cell Factory Methodology — LPN NCLEX-PN Preparation